plk1 inhibitor — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T2704	MLN0905	PLK1 Inhibitor	PLK
	MLN0905 (PLK1 Inhibitor) is an effective PLK1 inhibitor(IC50=2 nM).		PLK
T21678	3MB-PP1		PLK
	3MB-PP1 is a bulky purine analog and a Polo-like kinase 1 (Plk1) inhibitor. In cells expressing analog-sensitive Plk1 alleles, 3MB-PP1 blocks mitotic progression and cell division arise by targeting Plk1. 3MB-PP1 specifi...		PLK
T28904	T521	T 521	PLK
	T521 is a selective inhibitor of the PBD of Plk1 and shows no inhibitory effect on Plk2 and Plk3.		PLK
T15454	GW843682X	GW843682	VEGFR , PLK , CDK , PDGFR , Aurora Kinase
	GW843682X (GW843682) is a selective and ATP-competitive inhibitor of PLK1 and PLK3 (IC50s = 2.2 nM and 9.1 nM).		VEGFR , PLK , CDK , PDGFR , Aurora Kinase
T25969	Poloxin-2	Poloxin2,Poloxin 2	PLK
	Poloxin-2 is a potent and selective Plk1 PBD inhibitor with anti-tumour activity that reduces the protein level of Plk1 in HeLa cells.		PLK
T22700	Cyclapolin 9		PLK
	Cyclapolin 9 is a selective, potent, and ATP-competitive inhibitor of polo-like kinase 1 (PLK1) with an IC50 of 500 nM, and has not shown activity against other kinases.		PLK
TN3848	Dihydrobaicalein		PLK
	Dihydrobaicalein is a natural product from Scutellaria baicalensis, a PLK1 inhibitor (IC50:6.3 μM).Dihydrobaicalein inhibits VRK2 and PLK2.		PLK
T6173	BI 2536		Apoptosis , Epigenetic Reader Domain , PLK
	BI2536 is an effective Plk1 inhibitor (IC50: 0.83 nM). It has 4- and 11-fold greater selectivity than Plk2 and Plk3.		Apoptosis , Epigenetic Reader Domain , PLK
T1839	Mps1-IN-2		Kinesin , PLK
	Mps1-IN-2 is a potent, selective and ATP-competitive dual Mps1/Plk1 inhibitor.		Kinesin , PLK
T17008	TC-S 7005		PLK
	TC-S 7005 is an effective inhibitor of Polo-like kinases (IC50s: 214 nM, 4 nM and 24 nM for Plk1, Plk2, and Plk3).		PLK
T2271	SBE13 Hydrochloride	SBE 13 hydrochloride,SBE 13 HCl	Apoptosis , PLK , Autophagy
	SBE13 Hydrochloride (SBE 13 HCl) is an effective and specific PLK1 inhibitor (IC50: 0.2 nM); no inhibition om Aurora A kinase, Plk2/3.		Apoptosis , PLK , Autophagy
T2634	Ro3280	RO 3280,Ro5203280	PLK
	Ro3280 (Ro5203280) is an effective, specific inhibitor of PLK1(IC50=3, Kd=0.09 nM).		PLK
T6247	Onvansertib	NMS-P937,NMS-1286937	Apoptosis , PLK
	Onvansertib (NMS-1286937), an oral, specific Polo-like Kinase 1 (PLK1) inhibitor, is with IC50 of 2 nM. The specificity of NMS-P937 forPLK1 is 5000-fold higher over PLK2/PLK3.		Apoptosis , PLK
T2458	CID755673		Serine/threonin kinase
	CID755673 is an effective and specific cell-active inhibitor for PKD (IC50: 182 nM); exhibits selective PKD1 inhibition when compared with PLK1, AKT, CAMKIIα, CAK, and PKC isoforms.		Serine/threonin kinase
T2438	HMN-214	IVX-214,HMN214	PLK
	HMN-214 (IVX-214) is a potent PLK1 inhibitor with an average IC50 of 0.12 μM.		PLK
T6338	PHA-680632	PHA 680632,PHA680632	FGFR , PLK , Aurora Kinase
	PHA-680632 is potent inhibitor of Aurora A, Aurora B and Aurora C with IC50 of 27 nM, 135 nM and 120 nM, respectively. It has 10- to 200-fold higher IC50 for FGFR1, FLT3, LCK, PLK1, STLK2, and VEGFR2/3.		FGFR , PLK , Aurora Kinase
T6283	Wortmannin	SL-2052,KY-12420	ATM/ATR , DNA-PK , Serine/threonin kinase , PLK , PI3K , Antibiotic , Autophagy
	Wortmannin (SL-2052) is a PI3K inhibitor (IC50=3 nM) that is covalent and irreversible. Wortmannin is also an inhibitor of PlK1 and PlK3 (IC50=5.8/48 nM) that blocks autophagy.
T16750	Rigosertib	ON-01910	Apoptosis , FLT , PLK , PI3K , Bcr-Abl , CDK , PDGFR , Src
	Rigosertib (ON-01910) is a selective and non-ATP-competitive inhibitor of PLK1 (IC50: 9 nM). Rigosertib is a multi-kinase inhibitor and a selective anti-cancer agent, which induces apoptosis by inhibition of the PI3 kina...		Apoptosis , FLT , PLK , PI3K , Bcr-Abl , CDK , PDGFR , Src
T5818	Rigosertib sodium	Rigosertib,Estybon,ON-01910	Apoptosis , PLK , PI3K
	Rigosertib sodium (ON-01910), a non-ATP-competitive inhibitor of PLK1(IC50=9 nM), exhibits 30-fold higher specificity activity over Plk2 and no effect on Plk3.		Apoptosis , PLK , PI3K
T7200	TAK-960		PLK
	TAK-960 is an orally bioavailable, selective inhibitor of Plks with IC50 values of 0.8, 16.9, and 50.2 nM for Plk1, Plk2, and Plk3, respectively.		PLK